Mitochondrial Transplant for Cell Regeneration
MITO2i and Medicine By Design Co-Fund Project in Mitochondria and Regenerative Medicine
This project, co-funded by MITO2i and MbD led by Ana Andreazza, professor at the Faculty of Medicine, University of Toronto, aims to advance mitochondrial transplantation as a regenerative medicine tool. The project’s focus is on developing a stable mitochondrial delivery method using bioengineered materials, and studying mitotransplant efficacy in various tissues using organ-on-a-chip technology. Long-term goals include obtaining pre-clinical and safety data and conducting larger clinical trials for chronic diseases, specifically mitochondrial rare diseases.
Co-Investigators: Marcelo Cypel (Surgical director, Ajmera Transplant Centre, University Health Network), Milica Radisic (Professor, University of Toronto), Ori Rotstein (Vice-President Research & Innovation, Unity Health), Frank Gu (Professor, University of Toronto), Sowmya Viswanathan (Scientist, University Health Network).
ANA ANDREAZZACanada Research Chair in Molecular Pharmacology of Mood Disorders Professor Department of Pharmacology & Toxicology and Department of Psychiatry University of Toronto
MARCELO CYPELMD, MSc, FRCSC, FACS Senior Scientist, Toronto General Hospital Research Institute (TGHRI) Cancer Clinical Research Unit (CCRU), Princess Margaret Cancer Centre
MILICA RADISICCanada Research Chair (Tier 1) in Organ-on-a-Chip Engineering Professor (BME, ChemE) University of Toronto
FRANK GUNSERC Senior Industrial Research Chair in Nanotechnology Engineering Professor (ChemE) University of Toronto
ORI ROTSTEINMD, MSc, FRCSC, FACS
Vice President of Research and Innovation at Unity Health Toronto Professor and Associate Chair of the Department of Surgery University of Toronto
SOWMYA VISWANATHANAssistant Professor Division of Hematology, Department of Medicine, University of Toronto Scientist, Krembil Research Institute (Krembil)
David Bodenstein is a PhD student at the Andreazza Lab
DR. GABRIEL SIEBIGERDr. Gabriel Siebiger is a Master’s student in the Cypel Research Lab
Yimu Zhao is an NSERC Post-doctoral Fellow in the laboratory of the Radisic Lab
AARON CLASKYAaron Clasky is a PhD Student in Dr. Frank Gu’s lab.
Avinash Mukkala is a PhD candidate in the laboratory of Dr. Ori Rotstein
MITO2i and Ted Rogers Centre Co-Fund Project in Heart Research in Mitochondria and Cardiovascular Research
MITO2i has partnered with the Ted Rogers Center for Heart Research to initiate the first cardiovascular and mitochondria research call for the Toronto community. The objective of these Innovation Seed Grants is to generate new knowledge, promote innovation, and support interdisciplinary research and collaboration. In so doing, MITO2i and the Ted Rogers Centre supports impactful projects that possess the most promise in transforming how we prevent, diagnose, and treat mitochondrial disease, heart failure, and associated conditions.
SLAVA EPELMAN, ASSOCIATE PROFESSOR OF MEDICINE, UNIVERSITY OF TORONTO AND CO-PI: MILICA RADISIC, PROFESSOR OF ENGINEERING, COLLABORATORS: DR. GORDON KELLER AND DR. MICHAEL LAFLAMME FOR THEIR PROJECT ENTITLED “MACROPHAGE SUPPORT OF CARDIOMYOCYTE MITOCHONDRIAL HOMEOSTASIS UNDERLIES ENHANCED FUNCTION OF HUMAN BIOENGINEERED CARDIAC MICROTISSUES”.
MITO2i Brain and Mitochondria Innovation Grant Awardees
MITO2i announced the Brain and Mitochondria Innovation Seed Grant in November 2022 to support projects looking to investigate the role of mitochondria in brain diseases and disorders. The purpose of the grant is to address the unmet need to understand the complex relationship between mitochondrial diseases, mitochondrial dysfunction, and brain diseases. The objective of the Innovation grants is to generate new knowledge, promoting innovation and interdisciplinary research.
MITOCHONDRIAL EPILEPTIC ENCEPHALOPATHIES: ORGANOID STUDIES IN A PATIENT COHORT
PETER CARLEN (PROFESSOR, UOFT, SENIOR SCIENTIST, KREMBIL RESEARCH INSTITUTE) AND DANIELLE ANDRADE (Clinician, UHN)
ASSESSMENT OF THE EFFECTS OF NEURONAL MITOCHONDRIAL CALCIUM UNIPORTER DEFICIENCY ON MITOCHONDRIAL, NEURONAL, AND GAIT DEFICITS IN MALE AND FEMALE MECP2 DEFICIENT MICE
JAMES EUBANKS (PROFESSOR, UOFT, SENIOR SCIENTIST, KREMBIL RESEARCH INSTITUTE, UHN)