Project Titles

• Determining the role of PolG1 in eliminating deleterious mitochondrial DNA from the female germline
• Mapping the genetic interactions of TAZ: towards a functional wiring diagram of the mitochondrion
• C-terminus of HSP70 Interacting Protein in Mitochondrial Quality Control
• Surveying the TAZ mutational landscape in yeast and human cell

Project Titles

• Mitochondrial Transplant for Cell Regeneration
• Manipulation of Organ temperature and Metabolism for the Extension of Donor Lung Preservation Times
• Novel approaches to eliminate mutant mitochondrial DNA and transplantation in patient-derived induced-pluripotent stem cells
• Mitochondrial Transplantation to Lessen Hepatic Ischemia/Reperfusion Injury: Efficacy, Mechanisms & Translation
• Investigating the Relationship between the Mitochondria and Lung Transplant Success
• Mitochondrial transplantation as a rescue strategy for the treatment of injured lungs allocated for transplantation

Project Titles

• Guanine Quadruplex Structures in Mitochondrial Health and Disease
• Human cerebral organoids to assess and treat severe epileptic/mitochondrial encephalopathies
• Mitochondrial Epileptic Encephalopathies: Organoid Studies in a Patient Cohort
• Neuropsychiatric and Brain Imaging Phenotyping of primary Mitochondrial Diseases
• Investigation of the role of ClpP protease deficiency in Perrault syndrome with Leukodystrophy
• The epidemiology and health system impact of mitochondrial disease and psychiatric conditions in Ontario: A population-based study

Project Titles

Psychiatric Disorders and Mental Illness

• Establishing a novel role of mental illnesses associated gene, Fxrlin regulation of mitochondrial function in cortical neurons. Potential relevance for the mitochondrial function dysregulation in psychiatric disorders
• Mitochondrial Enhancers for Neuropsychiatric Diseases
• Age-selective adolescent amygdala astrocyte susceptibility to chronic delta9-tetrahydrocannabinol (THC)-induced mitochondrial oxidative stress
• Neuropsychiatric and Brain Imaging Phenotyping of primary Mitochondrial Diseases
• The epidemiology and health system impact of mitochondrial disease and psychiatric conditions in Ontario: A population-based study

Neurodegenerative Diseases and Aging

• The importance of mitochondrial dynamics in maintenance of neural stem cell function
• Mitochondrial dysfunction and cognitive improvements in cognitively impaired patients undergoing Exercise-primed AtDCS intervention
• C-terminus of HSP70 Interacting Protein in Mitochondrial Quality Control
• Identifying probiotics that modulate mitophagy in models of mitochondrial dysfunction
• Investigating the effects of phosphorylation of CHIP on alpha synuclein mediated mitophagy
• Mitochondrial Dysfunction in Mild Vascular Cognitive Impairment
• Comparing Mitochondrial Dysfunction as a Mediator of Oxidative Stress and Cognition between Vascular Mild Cognitive Impairment and Mild Cognitive Impairment due to Alzheimer’s Disease
• Investigating the role of Huntingtin-NEAT1 interactions in regulating mitochondrial bioenergetics in Huntington’s disease
• Mitochondrial and Neural Mechanisms of Photobiomodulation (PBM) in Early Alzheimer’s Disease (AD)
• Regulation of PINK1-Parkin Mitophagy by Molecular Chaperones

Neurodevelopmental Disorders

• Characterizing mitochondrial function and morphology in mouse models with GRIN1 patient variants
• Human cerebral organoids to assess and treat severe epileptic/mitochondrial encephalopathies
• Assessment of the effects of neuronal mitochondrial calcium uniporter deficiency on mitochondrial, neuronal, and gait deficits in male and female MECP2 deficient mice
• Mitochondrial Epileptic Encephalopathies: Organoid Studies in a Patient Cohort
• Investigation of the role of ClpP protease deficiency in Perrault syndrome with Leukodystrophy
• Identification of candidate genetic susceptibility variants in the carnitine transporter and carnitine biosynthesis gene families in Autism Spectrum Disorder: A novel precision medicine target

Project Titles

• Understanding mitochondrial protease ClpXP degradation machinery and its function in acute myeloid leukemia.
• Identification of mitochondrial nuclear export cargo and modulation by the XPO1 inhibitor selinexor in diffuse large B cell lymphoma
• Mitochondrial Metabolism Vulnerabilities in Breast Cancer

Project Titles

• The implications of dietary intervention on mitochondrial dysfunction in type 2 diabetes
• Identifying probiotics that modulate mitophagy in models of mitochondrial dysfunction
• Metabolic Regulation of Neutrophil Biology in a Murine Model of Severe Malnutrition

Project Titles

• The implications of dietary intervention on mitochondrial dysfunction in type 2 diabetes
• Elucidating the role of mitochondrial dysfunction in pancreatic endothelial cells in type 1 diabetes

Project Titles

• Mitochondrial and Metabolic Therapies for Heart Disease Based on the Regenerative Potential of the Pediatric Heart
• Assessing mitochondrial dysfunction due to SARS-CoV-2 infection in a heart-on-a-chip platform
• Surveying the TAZ mutational landscape in yeast and human cell
• Developing Metabolic Therapies for Heart Disease by Harnessing the Regenerative Potential of the Pediatric Heart
• Protein degradation and mitophagy defects in phospholamban R14d-linked cardiomyopathies.
• Macrophage Support of Cardiomyocyte Mitochondrial Homeostasis Underlies Enhanced Function of Human Bioengineered Cardiac Microtissues

Project Titles

• Manipulation of Organ temperature and Metabolism for the Extension of Donor Lung Preservation Times
• Investigating the Relationship between the Mitochondria and Lung Transplant Success

Project Titles

• Mitochondrial Transplantation to Lessen Hepatic Ischemia/Reperfusion Injury: Efficacy, Mechanisms & Translation

Project Titles

• The role of Rho in PKD-mediated mitochondrial remodeling
• Investigating Hepatocyte Nuclear Factor 4 Alpha as a Central Regulator of Kidney Graft Repair

Project Titles

• Human embryo mtDNA heteroplasmy dynamics and clinical significance of mtDNA variation in pre- implantation embryos from fertile and infertile populations
• Investigation of the role of ClpP protease deficiency in Perrault syndrome with Leukodystrophy

Project Titles

• Assessing mitochondrial dysfunction due to SARS-CoV-2 infection in a heart-on-a-chip platform